The RM-Z250 engine is based around an oversquare bore and stroke design, with liquid-cooling, titanium valves and double overhead billet cams. The engine is housed by a lightweight, twin-spar aluminum-alloy frame combining aluminum forgings, extrusions and stampings welded into a single unit. The whole package is supported by a Showa inverted, twin-chamber, cartridge fork and Showa remote reservoir rear shock.

The RM-Z250 features a unique aluminum rear swingarm built using hydro-formed, thick-wall tapered arms welded to a cast linkage bracket and forged axle holders. Other features include Dunlop tires mounted on lightweight aluminum rims with a special spoke / nipple design, plus Renthal aluminum handlebars as standard equipment. Included with this year's new model are all the benefits of Suzuki's race contingency, trackside support, Tony D School and Good scholar program. All these added benefits are exclusive to Suzuki riders.